1 Paris: It's good to be in space, where things are predictable.
2 Iki Piki: Bizarre space anomaly, dead ahead!
3 {beat}
4 Paris: See? This sort of thing happens all the time.

Realistically, we know pretty much everything that you might encounter when travelling through space. All the exciting and unpredictable stuff will take place on planets or other condensed bodies (stars, moons, comets, ateroids, etc.). In deep space there's pretty much nothing. A few hydrogen atoms isn't all that exciting.

Unless of course there really are bizarre anomalies that we don't even suspect.

The first people to leave the solar system are going to be either incredibly bored or incredibly terrified.