1 Galileo: Aren't you a little short to be an agent of the Devil?
2 Edmond Halley: Huh? No, I'm Edmond Halley. I'm here to rescue you! Quick, into the blue box.
3 Galileo: This looks like one of Leonardo's contraptions.
4 Galileo: Only his were never so clean inside. Empty pizza boxes everywhere...

I can just picture Leonardo da Vinci at work in his laboratory, making his sketches, hammering away on his helicopter prototypes until the wee small hours of the morning, and ordering pizza in for midnight snacks and leaving the empty boxes strewn around all over the place.

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2025-03-13 Rerun commentary: In our reality, Leonardo da Vinci was born 102 years before Galileo, and their lives did not overlap.

I was also going to write some stuff about when pizza boxes were invented, and became distracted by the surprisingly large amount of information on Wikipedia's page. The history is a little unclear. It claims that a corrugated cardboard pizza box was patented in 1963, but then also says that pizza historians assume that the pizza box was invented by Domino's but that the company never filed a patent for it. If both are true, then Domino's must have invented it before 1963, and then someone else later filed a patent for it. (Which should have been denied, since there would have been prior art.)

I did a search and the mentioned 1963 patent appears to be this one, assigned to a company named Chicken Delight. Since this was some 510 years after Leonardo was born, one may safely assume from the above comic that there was indeed prior art, and the patent should be invalidated. (Although it expired in 1981, so there's not much point, unless you want to time travel to a period between 1963 and 1981 and market bootleg pizza boxes.)