1 Isaac Newton: With my newfound perception of the universe, I have formulated a new theory of gravitation.
2 Isaac Newton: It says that the universe must have had a beginning, in a gigantic explosion of time and space that created everything.
3 Isaac Newton: Which means, my good friends, that the lives—and deaths—of all mortals...
4 Isaac newton: ... are ultimately the result of one primordial insanely overpowered fireball!
4 Death of Insanely Overpowered Fireballs: HUH.

It would have been nice if Newton had managed to somehow see how physics changed after him. Though ultimately he became one of the giants on whose shoulders later scientists stood to see further.